from entering the retina when iron levels are high, but if iron export from cells is unregulated, iron may accumulate in the eye and degrade the macula. The macula, a small portion of the retina which is responsible for sharp and detailed vision, deteriorates over time when the retinal pigment epithelium (RPE) surrounding the macula oxidizes triggering an inflammatory response. Home / Iron Blog, iron contributes to the leading causes of vision loss. But too much iron or problems with utilizing, storing, or transporting iron properly can lead to vision loss in the form of conditions such as age-related macular degeneration and hyperferritinemia syndrome, according to recent research findings. People with hhcs typically have normal tibc and TS test results but elevated serum ferritin levels (. Iron accumulates in the body with age because we continue to absorb it from our diets, but we excrete very little, Dunaief said. In hhcs, components of ferritin accumulate in the eye lens and crystalize disrupting the light transmission which enables a person to see.
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